Glabridin Whitening skin delay aging skin smooth CAS No 59870-68-7

Glabridin Whitening skin delay aging skin smooth CAS No 59870-68-7

Grade Standard

Medicine Grade,Cosmetic Grade

Certificate

GMP ISO USP Bp MW

324.37 Storage

Cool Dry Place

Shelf Life

2 Years Proper Storage

Assay :99.9% Min Glabridin

Type of Product

Cosmetic Glabridin

Einecs No

611-908-7

Sample

Glabridin Avaliable

MF

C20h20o4

CAS No

59870-68-7

Product Name

Glabridin

Appearance

White Powder

Active Ingredient

Glabridin

Transport Package

100g Per Bag

Specification

99% min Glabridin

Origin

Shaanxi China

Production Capacity

5000kg/Year

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Glabridin is a kind of flavonoid active ingredient derived from licorice root. It is a common skin whitening ingredient. Only 1g Glabridin can be extracted from per 500kg licorice root. And its whitening effect is 1000 times that of vitamin C. Therefore, it also enjoys the name of "Whitening Gold". Glabridin, as a major ingredient of licorice for skin, is mild and non-irritating

Function of Glabridin :

1. Glabridin has depigmentation and lightening properties. It inhibits the production of melanin, the pigment
responsible for the colouring of the skin;
2. Studies have show positive effects in fields like LDL(low-density lipoprotein ) protection against oxidation;
3. Glabridin inhibits the inflammatory reaction by blocking cyclooxygenase and preventing the formation of
free radicals such as superoxide anions;
4. At the same time Glabridin prevent rough skin and also has anti-inflammatory, antibacterial effect.

Application of Glabridin :

1. As a sweetener, licorice exatrct is used in food industry;
2. As as raw materials of drugs for clearing heat and detoxicating,licorice extract is used in medicine field;
3. As product for benefiting stomach, licorice extract is widely used in health industry;
4. Licorice extract applied in cosmetic field, licorice extract is able to nourish and cure the skin.

Glabridin (Gla) is a typical flavonoid isolated from the Glycyrrhiza glabra with various bioactivities and is a common additive in many cosmetics. In our study, we evaluated the antiscarring effect of Gla from G. glabra in a rabbit ear hyperplastic scar model. Hematoxylin and eosin staining and Masson staining were applied to determine the pathological changes and collagen fibers of scar tissue in rabbits. The results suggested that Gla could reduce rabbit ear scar hyperplasia, inhibit inflammation, and decrease collagen production. Furthermore, the in vitro cell experiments were applied to determine the effects of Gla on human keloid fibroblasts (HKFs), and we observed that Gla suppressed the HKF cells’ proliferation via inducing apoptosis. Subsequently, we found that Gla reduced collagen production in HKF cells. The further molecular mechanisms investigations suggested that Gla played a therapeutic role against keloid by attenuating PI3K/Akt and TGFβ1/SMAD pathways. Our study would be beneficial for extending the applications of the known sweet plant of G. glabra.