The nutraceutical world has a new star — and it comes from the humble citrus peel.
Nobiletin (CAS 478-01-3), a rare polymethoxyflavone exclusively found in mandarin and tangerine peels, is rapidly emerging as one of the most researched natural compounds in modern health science. With six methoxy groups on its flavone backbone — giving it exceptional bioavailability and metabolic stability — Nobiletin delivers a breadth of bioactivities that few single phytochemicals can match.
What makes Nobiletin stand out?
- Metabolic health pioneer: Nobiletin activates RORα/γ nuclear receptors and enhances circadian clock amplitude, directly attenuating metabolic syndrome — improving lipid metabolism, reducing insulin resistance, and protecting against hepatic steatosis in preclinical models.
- Anti-inflammatory powerhouse: By blocking NF-κB binding to DNA and promoting M2 macrophage polarization, Nobiletin suppresses pro-inflammatory cytokine expression at the molecular level — making it a compelling candidate for chronic inflammation management.
- Neuroprotective promise: Studies demonstrate Nobiletin's ability to reduce neuroinflammation, enhance neurotrophic activity, and improve memory impairment — positioning it at the frontier of cognitive health supplement development.
- Anti-cancer potential: From inducing apoptosis in NSCLC cells to inhibiting WNT/β-catenin signaling, Nobiletin shows multi-pathway anti-tumor activity across multiple cancer cell lines, supported by growing in vivo evidence.
Baisifu Nobiletin 98% — HPLC-verified purity, industry-ready quality
Baisifu Health now offers Nobiletin 98% (HPLC assay ≥98%), extracted from premium Citrus nobilis peel with full traceability from raw material to finished product. Every batch undergoes rigorous HPLC testing and is backed by complete COA, TDS, and MSDS documentation.
- Purity: ≥98% (HPLC)
- Appearance: White to off-white fine powder
- Molecular Formula: C₂₁H₂₂O₈ / MW 402.39
- Solubility: Soluble in DMSO and ethanol
- Packaging: 1kg–25kg, customizable
- Certifications: GMP, ISO9001, ISO22000, Kosher, Halal compliant
From citrus peel to cutting-edge formulation — Nobiletin is ready to elevate your next product.
Whether you're developing a metabolic health supplement, an anti-inflammatory functional food, or a cognitive wellness formula — Nobiletin 98% delivers the purity, potency, and documentation your R&D team demands.
